Fundamental Trade-Offs Between Information Flow in Single Cells and Cellular Populations



Event Details
Tuesday, November 13, 2018
Talk:
4:00 PM , 115 Avery Hall

Reception:
3:30 PM, 348 Avery Hall

Eric Deeds, Dr.

Associate Professor, University of Kansas

Abstract

Human cells have the remarkable capacity to self-organize their behavior in order to generate and maintain complex tissues and organ systems. Cells accomplish this largely through intercellular communication, using a combination of endocrine, paracrine, autocrine and contact signaling to coordinately regulate their activities. A major thrust of research in my lab is aimed at understanding the function of the cell signaling networks that process and interpret intracellular cues. One striking characteristic of human cell signaling networks is their heterogeneity: it has been found that, even within isogenic populations of the same cell type, different cells within the population often respond very differently to the same stimulus. This high degree of heterogeneity significantly limits the amount of information that individual cells can have about their environment. Using the framework of information theory, we recently demonstrated that high levels of heterogeneity can actually be advantageous, allowing tissues to exert precise control over processes like differentiation or cell death at the population level. Interestingly, we found that much higher levels of information flow were present when considering cases where individual cells, rather than populations, were being controlled by the input signal. This suggests that, rather than arising as an unavoidable consequence of noise in biochemical reaction networks, heterogeneity may in fact be highly regulated by particular cellular systems. Understanding the sources and physiological role of this heterogeneity is key to the development of approaches for treating cancer and other diseases where dysregulation of cell signaling plays a major role in the pathophysiology of the disease

Speaker Bio

Eric J. Deeds, Ph.D. is an Assistant professor in the Center for Computational Biology and the Department of Molecular Biosciences at the University of Kansas. The Deeds Lab uses computational approaches to understand the dynamics of complex protein interaction networks, with a focus on two main areas where protein interactions are vital to cellular function. The first of these is the assembly of macromolecular machines like the ribosome and proteasome, in which many distinct protein subunits must associate with one another in order to form the active enzyme. The second involves understanding how protein interactions allow cells to transmit and process extracellular information in order to mount appropriate responses to changes in their environment.